Albuterol sulfate and ipratropium bromide

ipratropium - albuterol inhaler and inhalation solution

By Watson Labs Florida

What side effects are possible with this medication?

A side effect is an unwanted response to a medication when it is taken in normal doses. It can be mild or severe, temporary or permanent, but does not occur in everyone. The following side effects have been reported by at least 1% of people taking this medication. If you develop any of these side effects (or any other side effects not listed here) or they change in intensity, speak to your doctor or pharmacist for advice on managing them and on the risks and benefits of the medication. 

  • bronchitis
  • change in taste sensation
  • chest pain
  • cold symptoms
  • coughing
  • dizziness
  • dry mouth
  • flu-like symptoms
  • headache
  • nausea
  • nervousness
  • pain
  • runny nose
  • shortness of breath
  • sore throat
  • tremor
Click here to learn about serious side effects that can potentially occur with any medication. These examples are provided for information purposes only and are not meant to be exhaustive. Always consult your doctor for sound medical advice specific to your particular medication and treatment.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online or by phone at 1-800-332-1088.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Activities requiring balance and clear vision: This medication may cause dizziness and blurred vision. Use caution when engaging in activities requiring balance and clear vision such as driving a car or operating appliances or machinery.

Allergic reaction: In rare cases, immediate allergic reactions may occur after administering ipratropium and albuterol causing hives, swelling around the throat and tongue, rash, and worsening of breathing problems. If this occurs, seek emergency medical help at once.

Cystic fibrosis: People with cystic fibrosis may be more likely to have stomach discomfort (due to changes in how quickly food moves through the stomach and intestines) while using this medication.

Eye problems: Avoid spraying the aerosol into your eyes. This may result in cause or worsening of narrow-angle glaucoma, mydriasis, increased intraocular pressure, acute eye pain or discomfort, temporary blurring of vision, visual halos, or colored images in association with red eyes from conjunctival and corneal congestion. If these symptoms develop, call your doctor immediately.

Kidney and liver problems: If you have poor liver or kidney function, you should be closely monitored by your doctor while using this medication.

Other medical conditions: If you have heart disease (including recent heart attack), abnormal heartbeat, glaucoma, high blood pressure, epilepsy, diabetes, increased thyroid hormone, enlarged prostate, bladder retention, and pheochromocytoma (a tumor of the adrenal gland), you should be closely monitored by your doctor while using this medication.

Paradoxical bronchospasm: This medication can produce paradoxical bronchospasm that can be life-threatening. If it occurs, the preparation should be discontinued immediately and alternative therapy instituted. It should be recognized that paradoxical bronchospasm, when associated with inhaled formulations, frequently occurs with the first use of a new canister.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, talk to your doctor about the benefits and risks of using this medication.

Breast-feeding: It is not known whether this medication passes into breast milk. If taking this medication is considered essential, stop breast-feeding.

Children: This medication is not recommended for children under 18 years of age. The safety and effectiveness of this medication have not been established for this age group.

What other drugs could interact with this medication?

There may be an interaction between ipratropium - albuterol and any of the following:

  • anticholinergic agents
  • beta-blockers (e.g., propranolol, nadolol)
  • diuretics (e.g., hydrochlorothiazide)
  • epinephrine
  • fenoterol
  • MAO inhibitors antidepressants (e.g., tranylcypromine, phenelzine)
  • sympathomimetics (e.g., norepinephrine)
  • terbutaline
  • tricyclic antidepressants (e.g., amitriptyline, desipramine)

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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Reviewer: Marlene Krempasky
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